Lisinopril HCTZ general information

The active substance (INN), Lisinopril (Lisinopril)

The use of Lisinopril (Lisinopril):

Hypertension (mono-and combination therapy), including renovascular, acute myocardial infarction in clinically stable patients, heart failure (special treatment), including: asymptomatic left ventricular heart failure on a background of acute myocardial infarction, postinfarction period, diabetic nephropathy.

Contraindications Lisinopril (Lisinopril):

Hypersensitivity, pregnancy, breast-feeding.

Restrictions apply:

Assessment of risk-benefit ratio is required in the following cases: anaphylactoid reactions, angioneurotic edema history, collagen, bone marrow depression (leukopenia, agranulocytosis), tserebrovaskulyatornaya failure, hypotension, renal failure and liver failure, aortic, mitral stenosis, or others . obstructive changes that impede the outflow of blood from the heart, hyperkalemia, or high risk of its occurrence (diabetes mellitus, severe renal insufficiency, concomitant use of diuretics), hyponatremia, or restriction of sodium in the diet, bilateral renal artery stenosis or stenosis of the artery of a sole kidney, the presence of the transplanted kidney, hyperuricemia, gout, children's age (safety and efficacy have not decided) and old age.

The use of Lisinopril (Lisinopril) during pregnancy and lactation:

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects: of the nervous system and sense organs:

headache, dizziness, impaired consciousness, irritability, nervousness, transient ischemic attack, syncope, ataxia, memory loss, drowsiness, insomnia, peripheral neuropathy, paresthesia, tremors, convulsions, visual disturbances (diplopia, photophobia, reduced visual acuity), ringing in the ears. Cardio-vascular system and blood (blood, hemostasis): palpitations, chest pain, hypotension, arrhythmia (atrial and ventricular tachycardia, atrial fibrillation, bradycardia, etc.), cardiac arrest, myocardial infarction, orthostatic reactions, vasculitis, depression bone marrow,

Interaction:

The hypotensive effect of diuretics increase, weakens - indomethacin. When combined with nitrates, propranolol, and digoxin were observed clinically significant adverse pharmacokinetic interactions. Increases the toxicity of lithium. Potassium-sparing diuretics, potassium supplements and potassium containing medications increase the risk of hyperkalemia.

Overdose Symptoms: acute hypotension.

Treatment: introduction of saline and other symptomatic therapy. Removed by hemodialysis.

Dosage and Administration:

Lisinopril HCTZ shold be taken inside, the adults one time per day. The dose is determined individually, depending on the evidence, the state of renal function and concomitant therapy. Typically, the initial dose is 5 mg, the mean maintenance dose - 5-20 mg, the maximum daily - 80 mg.


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Lisinopril HCTZ